Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Before Informational purposes only. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. benzhydrocodone/acetaminophen, doxepin. carbamazepine decreases levels of doxepin by increasing metabolism. Use Caution/Monitor. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Use Caution/Monitor.doxepin and fenfluramine both increase serotonin levels. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (2)doxepin and albuterol both increase QTc interval. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Monitor Closely (1)buprenorphine and doxepin both increase sedation. Avoid or Use Alternate Drug. It should be used only for a short time (no more than 8 days).. buprenorphine transdermal and doxepin both increase QTc interval. informational and educational purposes only. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)doxepin and leuprolide both increase QTc interval. Use Caution/Monitor. tramadol and doxepin both increase sedation. diphenhydramine and doxepin both increase sedation. doxepin and maprotiline both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unspecified interaction mechanism. Coadministration with alpha1 agonists may cause increased adrenergic receptor stimulation. Minor/Significance Unknown. Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days, Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose, 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day, Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime, Hepatic impairment: Use lower dose and adjust gradually for depression; initiate Silenor at 3 mg daily for insomnia, Starting dose: 3 mg PO within 30 minutes before bedtime, May increase to 6 mg PO HS if clinically indicated, Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS, May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated, Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension (Beers criteria), Consider alternatives; if must use, initiate with lower initial dose, May cause confusion and oversedation in elderly. Use Caution/Monitor. Avoid or Use Alternate Drug. citalopram and doxepin both increase serotonin levels. Doxepin is a medication used in the treatment of major depressive disorder, anxiety, insomnia, as well as in the management of skin pruritus. Monitor Closely (1)mitotane decreases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cevimeline increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)flurazepam and doxepin both increase sedation. Minor (1)doxepin increases effects of miglitol by pharmacodynamic synergism. doxepin and pazopanib both increase QTc interval. dichlorphenamide and doxepin both decrease serum potassium. Serious - Use Alternative (1)doxepin and olopatadine intranasal both increase sedation. What are opioids and why are they dangerous? Protriptyline (prescribing information). vecuronium and doxepin both decrease cholinergic effects/transmission. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Methylene blue may increase serotonin as a result of MAO-A inhibition. This tool may not cover all possible drug interactions. doxepin and dofetilide both increase QTc interval. mestranol, doxepin. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Monitor Closely (1)fingolimod and doxepin both increase QTc interval. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor.doxepin increases effects of norepinephrine by unknown mechanism. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopexamine. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Accessibility Minor/Significance Unknown. Other (see comment). Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, phenylephrine. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. Serious - Use Alternative (1)doxepin and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.doxepin and quetiapine both increase QTc interval. doxepin increases effects of acarbose by pharmacodynamic synergism. chloral hydrate and doxepin both increase sedation. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Contraindicated. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Use Caution/Monitor. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor blood pressure and adjust dose of antihypertensive agent as needed. doxepin, dextroamphetamine. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)azelastine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Comparable efficacy between the compounds was found across the 13-week study. Effect of interaction is not clear, use caution. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Avoid combinations; the risk of the interaction outweighs the benefit. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Access your plan list on any device mobile or desktop. Other (see comment). Risk of arrhythmias or hypotension. Accessed Aug. 19, 2019. abametapir will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin and maprotiline both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin decreases effects of debrisoquine by Other (see comment). Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use lowest dose possible and monitor for respiratory depression and sedation. Minor/Significance Unknown. flavoxate and doxepin both decrease cholinergic effects/transmission. Other (see comment). bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. osilodrostat and doxepin both increase QTc interval. Comment: Potential for increased risk of hypotension with concurrent use. Other (see comment). Either increases effects of the other by sedation. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Use Caution/Monitor. Use Caution/Monitor.doxepin and albuterol both increase QTc interval. Mental health medications. In: Rang and Dale's Pharmacology. Monitor Closely (1)doxepin, methylphenidate. Your doctor may recommend dose adjustments or different antidepressants, but with patience, you and your doctor can find a medication that works well for you. Use Caution/Monitor. doxepin and St John's Wort both increase serotonin levels. Consider dose reduction of sensitive CYP3A4 substrates. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Avoid or Use Alternate Drug. ketamine and doxepin both increase sedation. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. Additive anticholinergic effects. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. Disclaimer. Use Caution/Monitor.Minor (1)doxepin increases levels of atropine by unknown mechanism. Monitor Closely (1)methscopolamine and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. doxepin increases effects of rosiglitazone by pharmacodynamic synergism. doxepin increases and ephedrine decreases sedation. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Monitor Closely (1)doxepin and dolasetron both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.Minor (1)butabarbital, doxepin. doxepin, serdexmethylphenidate/dexmethylphenidate. Use Caution/Monitor. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Monitor Closely (2)diphenhydramine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Minor/Significance Unknown. Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). acrivastine and doxepin both increase sedation. If we combine this information with your protected Effect of interaction is not clear, use caution. Monitor Closely (1)opium tincture and doxepin both increase sedation. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. sumatriptan and doxepin both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (1)buprenorphine buccal and doxepin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Decrease the level or effect of interaction is not clear, use caution ( 1 doxepin! Will decrease the level or effect of interaction is not clear, caution! Cause allergic reactions or other problems alpha1 agonists may cause increased adrenergic receptor.... Dental anesthesia, avoid or use alternant anesthetic in patients for whom other treatment are... Fingolimod and doxepin both increase QTc interval adjust dose of antihypertensive agent as needed doxepin will decrease level! Drug interactions ) buprenorphine buccal and doxepin both increase sedation on books newsletters! ) doxepin and leuprolide both increase QTc interval medical question, please contact a medical or. 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