Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. If you feel dizzy from Zetia, it may help to take your dose at bedtime. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. stuffy nose. Zetia and Lipitor are both brand-name drugs. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. Covers lawsuits, malpractice, class actions, fraud, legislation, regulation, enforcement. Statins lower cholesterol by preventing your liver from making new cholesterol. You should also look for supplements from reputable manufacturers. However, if youre taking Zetia with a statin drug, youll need to avoid eating grapefruit or drinking grapefruit juice. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. dark colored urine. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. In addition, you may need to watch out for grapefruit. For HoFH, Zetia is FDA-approved to decrease levels of total cholesterol and LDL cholesterol. Statin drugs may pass into breast milk. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Your doctor will determine the best dosage to fit your needs. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. Medications in this drug class prevent your liver from making new cholesterol. Once diagnosed, many patients face waiting lists as long as two years to get . Talk with your doctor about the risks of taking Zetia with warfarin. Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Ways to reduce the symptoms. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. These tests will look at your cholesterol levels and also your liver enzyme levels. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. The generic form of Zetia costs about the same as the generic form of Crestor. For more information, see Liver problems in the Precautions section below. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). stomach pain. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. shaking and sweating. Leqvio is a prescription drug used to lower cholesterol. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. These drugs havent been directly compared in clinical studies. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Yes, treatment with Zetia should lower your triglycerides. If youre taking Zetia alone, you shouldnt need to take CoQ10. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. Fenofibrate belongs to the fibrate drug class. (A class of drugs is a group of medications that work in a similar way.) However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. For more information about Zetia, including details about its uses, see this in-depth article on the drug. To help make sure you dont miss a dose, try setting a reminder on your phone. Learn more about some of the side effects that Zetia may cause. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. It can cause mild side effects and, less commonly, serious side effects. Its intestinal molecular target is the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter. Zetias side effects are usually mild, especially if youre taking Zetia alone. I take pravastatin 80mg with absolutely no problem. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Below are examples of these side effects. There are no known interactions between Zetia and alcohol. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). But new medications can help lower cholesterol and improve heart health. This in turn increases clearance of cholesterol from the blood. Get medical help right away, if you have any of the symptoms listed above. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. No, clinical studies havent shown Zetia to affect blood pressure. Zetia may be used with statin drugs or with fenofibrate when used to treat certain conditions. Zetia contains the active drug ezetimibe. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Zetia is also available in a generic form called ezetimibe. We talked to experts about, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. What causes POTS? The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo (a treatment with no active drug). Tried Zetia again to rule out diet causing stomach issues but got same result. Zetia does not cause an increase or a decrease in blood pressure. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. At the end of the study, researchers found that: Mixed hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol and fats are cleared from your body. It belongs to a class of drugs called cholesterol absorption inhibitors. You may be able to find testimonials online from people who take Zetia. Ezetimibe may cause side effects. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. An allergic reaction is possible after using Zetia. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). * For more information about this side effect, see " Zetia: Side effects explained " below. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. You likely wont notice Zetia working in your body. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. However, some people have reported experiencing memory loss when taking statin drugs. (Fenofibrate is a drug used to lower your triglyceride levels.). The insurance company will review the prior authorization request and decide if the drug will be covered. However, it isnt known how Zetia may affect these risks. Our website services, content, and products are for informational purposes only. You can use the study as a second opinion to make health care decisions. Grapefruit can prevent the breakdown of these drugs in your body. Zetia is metabolized in the small intestine and liver. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). This drug has not been studied in pregnant females.*. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Zetia is approved to treat different types of high cholesterol. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. fainting (passing out) problems with thinking, memory and concentration - this combination of symptoms is often called 'brain fog'. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. Most of Zetias side effects should go away within a few days or weeks. Inability to speak. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. Short term Zetia side effects include mild fatigue, dizziness, diarrhea, nausea and headache. 5.8k views Answered >2 years ago. Absorption isnt affected by food. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. This causes less cholesterol to travel from your small intestine to your liver. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. * Sex and gender exist on spectrums. Both Zetia and Crestor come as tablets that are swallowed. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. * This is a partial list of mild side effects from Zetia. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. You should take Zetia according to the instructions of your doctor or another healthcare professional. People with this condition have high levels of LDL (bad) cholesterol. Zetia comes as a tablet that you swallow. They may be able to help determine whats causing your hair loss. In studies, some people had to stop taking Zetia because of this side effect. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. Read More. Some people with POTS also may have one or more . You can learn more about how we ensure our content is accurate and current by reading our. Statins are drugs used to lower cholesterol. Total cholesterol is the overall amount of cholesterol found in your blood. Dr. John Szawaluk answered. The generic form of Zetia costs about the same as the generic form of Lipitor. People with this condition have high levels of plant sterols. Drugs in this class prevent your small intestine from absorbing cholesterol. Do my other medications increase my risk of side effects with Zetia? tender, swollen glands in neck. See the Zetia prescribing information for details. Talk with your doctor about birth control options that may be best for you. Doing this can raise your risk of side effects. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . Tell them about all prescription, over-the-counter, and other drugs you take. Get emergency medical help if you have signs of an allergic reaction to Zetia: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your doctor if youre experiencing bothersome side effects from Zetia. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. An increase in these liver enzymes while using a statin drug can cause severe liver disease. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. Zetia comes as a tablet that you swallow. Examples of statin drugs include: Learn more about how grapefruit may interact with medications. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. People with HoFH have high levels of LDL (bad) cholesterol. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. Zetia is a brand-name drug that contains the active drug ezetimibe. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Its primary metabolic pathway is via hepatic glucuronic conjunction. Hot and cold spells. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. More research is needed to know for sure. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. However, be sure to take the dosage your doctor prescribes for you. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. 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